Santiago Cano-Muniz

Santiago Cano-Muniz

AI Bioinformatics @ BigOmics, Lugano, CH. Biology + Data Science = 💣

Publications

Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli.

Published in Nature Microbiology, 2025

Porins mediate the passage of hydrophilic nutrients and antibiotics across the outer membrane but might contribute to proton leak from the periplasm…

Recommended citation: Caño Muñiz, Santiago E., et al. "Metabolic Control of Porin Permeability Influences Antibiotic Resistance in Escherichia Coli." Nature Microbiology, vol. 10, no. 12, 2025, pp. 3202-3214, https://doi.org/10.1038/s41564-025-02175-5. Accessed 4 Dec. 2025.
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Ionic control of porin permeability in bacteria.

Published in BioarXiv, 2022

Here we show, in Escherichia coli, that porin permeability is controlled by changes in periplasmic ions, inhibited by periplasmic acidification, …

Recommended citation: CANO MUNIZ, Santiago, et al. Ionic control of porin permeability in bacteria. bioRxiv, 2022, p. 2022.07. 13.499887.
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Persisters and pH

Published in AMS journal, 2021

One of most impressive featatures of bacteria is their ability to develop resistance to antibiotics, rendering these life-saving drugs ineffective. In this study developed in collaboration with some colleagues at the Uni of Exeter

Recommended citation: GOODE, Olivia, et al. Persister Escherichia coli cells have a lower intracellular pH than susceptible cells but maintain their pH in response to antibiotic treatment. MBio, 2021, vol. 12, no 4, p. e00909-21.
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New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State

Published in Journal 1, 2017

We are far away from the days when tuberculosis (TB) accounted for 1 in 4 deaths during the 19th century. However, Mycobacterium tuberculosis complex (MTBC) strains are still the leading cause of …

Recommended citation: CAÑO-MUÑIZ, Santiago, et al. New approaches and therapeutic options for Mycobacterium tuberculosis in a dormant state. Clinical microbiology reviews, 2018, vol. 31, no 1, p. e00060-17.
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Indole and the metabolic pathways

Published in New biotechnology, 2016

This work was producing during my time at Summers Lab. In this study, we examined the effect of indole on the anaerobic metabolism of E. coli. We added indole in to the culture medium and compared cell growth, …

Recommended citation: DE LEON-RODRIGUEZ, Antonio, et al. Indole modifies the central carbon flux in the anaerobic metabolism of Escherichia coli: application to the production of hydrogen and other metabolites. New biotechnology, 2016, vol. 33, no 6, p. 868-873.
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The wonders of the indole pulse

Published in Scientific reports, 2015

This paper is the result of some work that I did when I was working in the Summers Lab (Department of Genetics, University of Cambridge). The research is about pH homeostasis in bacteria. They .

Recommended citation: ZARKAN, Ashraf, et al. Indole pulse signalling regulates the cytoplasmic pH of E. coli in a memory-like manner. Scientific Reports, 2019, vol. 9, no 1, p. 1-10.
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